Pathologic changes in patients infected with SARS-CoV-2: a review

نویسندگان

چکیده

Severe acute respiratory syndrome–coronavirus-2 (SARS-CoV-2) enters cells using the angiotensin converting enzyme 2 (ACE2), which are expressed by tract endothelium, epithelial of stomach, duodenum, ileum, rectum, cholangiocytes, and hepatocytes. Pathological examinations these organs not feasible method diagnosis but can explain pathological changes, pathogenesis disease, cause death in COVID-19 cases. In this review, we performed a literature search for COVID-19-related changes seen during post-mortem different body including lungs, gastrointestinal tract, liver, kidney, skin, heart blood. Our findings showed that SARS-CoV-2 has damaging effects on many organs, probably due to host immune responses presence virus. It is recommended both antiviral immunomodulatory agents should be considered management patients better prognosis, clinical outcome.
 
 French title: Changements pathologiques chez les infectés par le SRAS-CoV-2: une revue
 Le syndrome respiratoire aigu sévère-coronavirus-2 pénètre dans cellules à l'aide de l'enzyme conversion l'angiotensine qui est exprimée l'endothélium des voies respiratoires, épithéliales l'estomac, du duodénum, l'iléon, et hépatocytes. Les examens ces organes ne sont pas méthode diagnostic réalisable, mais peuvent expliquer changements pathologiques, la pathogenèse maladie décès cas COVID-19. Dans cette revue, nous avons effectué recherche bibliographique sur liés au observés lors d'examens différents corps, notamment poumons, tractus gastro-intestinal, foie, reins, peau, coeur sang. Nos résultats ont montré que SRAS-CoV-2 effets néfastes nombreux organes, probablement en raison réponses immunitaires l'hôte présence Il recommandé antiviraux immunomodulateurs soient pris compte prise charge pour un meilleur pronostic cliniques.

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ژورنال

عنوان ژورنال: African Journal of Clinical and Experimental Microbiology

سال: 2021

ISSN: ['1595-689X']

DOI: https://doi.org/10.4314/ajcem.v22i4.1